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Comparison of Pulsating Flow of Newtonian and non-Newtonian Fluid in Complex Geometry
Kohút, Jiří ; Rudolf, Pavel (referee) ; Jagoš, Jiří (advisor)
This master's thesis deals with pulsating flow of Newtonian and non-Newtonian fluid. Theoretical part represents necessary theoretical knowledge for pulsating flow and understanding of non-Newtonian behaviour. Furthermore the thesis focus is directed on numerical simulation of pulsating flow in straight, ideally rigid tube and in patient-specific model of human artery, more precisely in carotid. Two methods are used: numerical solution based on finite volume method (FVM) and also analytical solution using Bessel functions by Womersley. Results are validated against experimental measurements of velocity profiles by particle image velocity method (PIV). The agreement between numerical and experimental data with consideration of PIV inaccuracy was was very good from both point of views - qualitative and quantitative. Numerical solution also compare influence of turbulence and non-Newtonian behaviour towards base (laminar flow, Newtonian fluid). Developed methodology is then applied on patient-specific model of carotid, which was renovated from computed tomography. Measurements in vivo in human arteries is very expensive and often invasive. Because of that measurement outputs are limited, most of the time on pressure and flow. Computational fluid dynamics (CFD) is non-invasive and outputs are through whole domain. Due to these advantages CFD significantly contributes to understanding of hemodynamics influence in cardiovascular diseases.
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Long-term Analysis of Ultrasound Video Sequences Using Interest Point Detectors
Zukal, Martin ; Závodná, Eva (referee) ; Papež,, Václav (referee) ; Říha, Kamil (advisor)
This doctoral thesis deals with the analysis of ultrasound (US) video sequences. It specifically focuses on long-term tracking of the common carotid artery (CCA) in transversal section and measurement of its geometric parameters in a sequence of US images. The design and implementation of a system for automatic tracking of the artery is described in this thesis. The proposed system utilizes Viola-Jones detector and Hough transform to localize the artery in the image. Interest points are detected in the area of the artery wall. These points are then tracked using optical flow. The proposed system comprises a number of innovative methods which allow to perform accurate long-term measurement of parameters of CCA and store the results. A novel mathematical model describing the movement of CCA in transversal section during a cardiac cycle is defined afterwards taking the influence of breathing into consideration. A number of artificial sequences of US images based on this model have been created. These sequences were consequently used to evaluate the accuracy of the proposed system in terms of measuring the parameters of CCA. The sequences are unique because of their length which makes them suitable for evaluation of tracking accuracy even in long video sequences.
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Analysis of impact of mechanical properties of components of pathological arterial wall on its state of stress
Bartoňová, Petra ; Konvalinka, Jan (referee) ; Burša, Jiří (advisor)
The thesis deals with measurements of the atherosclerothic carotid plaques mechanical properties with wiew towards the improvements of their constitutive models and then towards the impact of application of those constitutive models in fibrous cap. The introductory part provides a brief summary of medical knowledge needed to understand atheroma formation and the risks involved. Next, there's a survey of plaque mechanical testing methods and the obtained results on tissue properties. The previously used constitutive models of atherosclerothic tissues are listed as well. Main body of the thesis describes the preparation of testing samples from obtained atheroma, methodology and course of experiments execution and subsequent processing of the experimental data to evaluate the behavior of the atheromatous tissue individual parts. Then the discussion and evaluation of our results and findings is given. Along with the evaluated mechanical properties, experimental data fitted to models are presented with respect to their predictive abilities. The final part is dedvoted to the finite element analysis of an idealized 2D model with emphasis on the effect of necrotic core and fibrous tissue properties on von Mises equivalent stress in the fibrous cap.
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Design of a model of the human carotid artery based on an electrohydraulic analogy
Škrlová, Nikola ; Kohút, Jiří (referee) ; Jagoš, Jiří (advisor)
The carotid artery plays a crucial role in delivering blood to the cerebral system, which ensures the proper function of the human body. Mathematical models of the cardiovascular system have been proposed to understand vascular disease. The main aim of this study is to create mathematical model of the carotid artery, using an electrohydraulic analogy. The most basic or 0D modeling of cardiovascular system includes the two-element Windkessel model. Numerical modeling was carried out in the MATLAB environment. To make the model solvable, it was necessary to determine the initial flow parameters in the common carotid. It was necessary toadjust the resulting pressure curves on the common carotid to the ideal pressure range of a healthy person. A similar process was performed for the flow in the internal carotid. Then a comparison was made with the real measured flow curve. During the verification of the law of mass conservation of the flow, a 6% deviation was discovered. This discrepancy is attributed to the process of obtaining flow values from the equations assembled in Chapter 5, as well as the rounding error inherent in MATLAB itself. This breakthrough combination of science and medicine is primarily beneficial for doctors and patients who are dealing with the disease.
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Stress-strain Analysis of Carotid Arteries with Atheroma
Lisický, Ondřej ; Návrat, Tomáš (referee) ; Vimmr, Jan (referee) ; Burša, Jiří (advisor)
Kardiovaskulární příhody byly a jsou rozšířenou příčinou úmrtí ve většině zemí. Ateroskleróza karotických tepen mnohdy vedoucí k mrtvici je jejich nedílnou součástí. Včasná a vhodně mířená diagnostika rizikových lézí může vést ke snížení kritických příhod, a tím potenciálně snížit počet úmrtí. Porušení nestabilního aterosklerotického plátu je ovlivněno působením sil od proudící krve. V biomechanice měkkých tkání je využíváno výpočtového modelování jakožto potenciálního ukazatele, díky němuž by bylo možné odhalit nestabilitu plátu u pacientů podstupujících pravidelná kontrolní měření. Mechanické veličiny bývají spojovány s klinicky dostupnými ukazateli jako jsou například podstatné rozměry léze nebo přítomnost rizikových komponent. Komplexita a malé rozměry tkáně ovšem stále omezují možnosti tvorby výpočtových modelů a existuje tedy spousta faktorů, které je před možnou implementací do klinických postupů potřeba řádně vyšetřit. Tato práce je členěna do kapitol shrnujících aktuální stav řešené problematiky. Kapitoly jsou doplněny o komentář autorova příspěvku k dané problematice a odkaz na originální práci. Studium problematiky naznačilo velké množství potenciálních směrů výzkumu, což by ovšem nebylo možné zahrnout do jediné práce. Řešená témata se dají rozdělit na: (i) ověření možnosti tvorby 3D výpočtového modelu ze snímků aterosklerotického plátu s následným rozšířením na výpočtovou studii zahrnující řadu faktorů pro ověření vlivu na napjatost, (ii) studium mechanických vlastností aterosklerotických plátů odebíraných z endarterektomie během celé doby řešení, (iii) možnosti analýzy deformačního pole u experimentů zahrnujících měkké tkáně a (iv) experimentální a výpočtovou studii zbytkové deformace, potažmo napětí v souvislosti s karotickými tepnami. Výsledky jednotlivých částí jednoznačně poukázaly na problémy spojené s výpočtovým modelováním jako například časté opomíjení přítomnosti komponent stěny tepny při modelování aterosklerotického plátu, nutnost správného pochopení mechanického chování, ale také na způsob vyhodnocení experimentů s vyšším počtem vzorků. V neposlední řadě bylo ukázáno, že zbytkové napětí nemusí být podstatným faktorem u aterosklerotických plátů karotických tepen.
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Analysis of impact of mechanical properties of components of pathological arterial wall on its state of stress
Bartoňová, Petra ; Konvalinka, Jan (referee) ; Burša, Jiří (advisor)
The thesis deals with measurements of the atherosclerothic carotid plaques mechanical properties with wiew towards the improvements of their constitutive models and then towards the impact of application of those constitutive models in fibrous cap. The introductory part provides a brief summary of medical knowledge needed to understand atheroma formation and the risks involved. Next, there's a survey of plaque mechanical testing methods and the obtained results on tissue properties. The previously used constitutive models of atherosclerothic tissues are listed as well. Main body of the thesis describes the preparation of testing samples from obtained atheroma, methodology and course of experiments execution and subsequent processing of the experimental data to evaluate the behavior of the atheromatous tissue individual parts. Then the discussion and evaluation of our results and findings is given. Along with the evaluated mechanical properties, experimental data fitted to models are presented with respect to their predictive abilities. The final part is dedvoted to the finite element analysis of an idealized 2D model with emphasis on the effect of necrotic core and fibrous tissue properties on von Mises equivalent stress in the fibrous cap.
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Comparison of Pulsating Flow of Newtonian and non-Newtonian Fluid in Complex Geometry
Kohút, Jiří ; Rudolf, Pavel (referee) ; Jagoš, Jiří (advisor)
This master's thesis deals with pulsating flow of Newtonian and non-Newtonian fluid. Theoretical part represents necessary theoretical knowledge for pulsating flow and understanding of non-Newtonian behaviour. Furthermore the thesis focus is directed on numerical simulation of pulsating flow in straight, ideally rigid tube and in patient-specific model of human artery, more precisely in carotid. Two methods are used: numerical solution based on finite volume method (FVM) and also analytical solution using Bessel functions by Womersley. Results are validated against experimental measurements of velocity profiles by particle image velocity method (PIV). The agreement between numerical and experimental data with consideration of PIV inaccuracy was was very good from both point of views - qualitative and quantitative. Numerical solution also compare influence of turbulence and non-Newtonian behaviour towards base (laminar flow, Newtonian fluid). Developed methodology is then applied on patient-specific model of carotid, which was renovated from computed tomography. Measurements in vivo in human arteries is very expensive and often invasive. Because of that measurement outputs are limited, most of the time on pressure and flow. Computational fluid dynamics (CFD) is non-invasive and outputs are through whole domain. Due to these advantages CFD significantly contributes to understanding of hemodynamics influence in cardiovascular diseases.
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Nursing care in anestesiology for a patient undergoing endarterectomy
Mocková, Karolína ; Di Cara, Veronika (advisor) ; Pucholtová, Romana (referee)
The subject of my bachelor thesis is a description of nursing process for the patients in anesthesia during the endarterectomy. By myself, I find this topic very interesting, because the disease of the cerebrovascular system is currently the most frequent disease. Stenosis of carotids is responsible for the one-third cases of stroke. In most cases is asymptomatic. Stenosis of carotids is more frequent in the age of 60 and higher. The goal of my bachelor thesis is to describe the nursing process on the operating theatre during the endarterectomy and the differences in the nursing process for the patients in a general anesthesia and locoregional anesthesia. Point out the importance of the cooperation between anesthesiology team and surgical team. In my bachelor thesis, I used the method of the case study of the patient on the operating theatre in the county hospital. For my thesis I have used following sources: Czech or foreign professional literature, Czech or foreign scientific articles, my own observations and providing professional nursing care, interview with the patient, information from health care personnel and patient's medical documentation. Analyzing of the nursing care I found that the healthcare professionals follow the nursing standards and recommended procedures. I found also the...
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Long-term Analysis of Ultrasound Video Sequences Using Interest Point Detectors
Zukal, Martin ; Závodná, Eva (referee) ; Papež,, Václav (referee) ; Říha, Kamil (advisor)
This doctoral thesis deals with the analysis of ultrasound (US) video sequences. It specifically focuses on long-term tracking of the common carotid artery (CCA) in transversal section and measurement of its geometric parameters in a sequence of US images. The design and implementation of a system for automatic tracking of the artery is described in this thesis. The proposed system utilizes Viola-Jones detector and Hough transform to localize the artery in the image. Interest points are detected in the area of the artery wall. These points are then tracked using optical flow. The proposed system comprises a number of innovative methods which allow to perform accurate long-term measurement of parameters of CCA and store the results. A novel mathematical model describing the movement of CCA in transversal section during a cardiac cycle is defined afterwards taking the influence of breathing into consideration. A number of artificial sequences of US images based on this model have been created. These sequences were consequently used to evaluate the accuracy of the proposed system in terms of measuring the parameters of CCA. The sequences are unique because of their length which makes them suitable for evaluation of tracking accuracy even in long video sequences.
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